DuPont will become a stand-alone company when it splits from DowDuPont on June 1.Replicating NatureSynthetic HMOs come from the formula industry’s quest to manufacture a breast-milk substitute that’s as close to the real thing as possible.’’While some research indicates advantages to HMO-enhanced formula, it’s not clear that there’s a long-term health difference, Abrams said.

The purported benefits are still viewed with skepticism by some in the scientific community — especially when they come at a premium price.Human milk oligosaccharide is the third most common solid in breast milk, after lactose and fat. Now the companies are eyeing a potentially bigger customer: adults.Among Abbott’s customers was Heidi Haydock, a senior manager at Cardinal Health Inc.Widening MarketBASF began scaling up production of 2’FL earlier this year, and it’s studying how the different health effects of HMOs might be developed into a range of products beyond baby formula.

DuPont is marketing its 2’FL HMO, branded as CARE4U, to consumer manufacturers who can use it in adult supplements for digestive and immune health, said Ratna Mukherjea, global research and development leader at DuPont. It sells 28 doses on Amazon. HMOs may explain why breast-fed babies tend to fare better than formula-fed, said Rachael Buck, who leads HMO research at Similac formula-maker Abbott Laboratories. and BASF SE are investing millions to ramp up production of auto rubber Suppliers an indigestible sugar found naturally in breast milk., who two years ago wasn’t able to breast feed her newborn son because she was undergoing chemotherapy for breast cancer.After two decades of research, Abbott was first to bring HMOs to the U. Mother’s milk isn’t just for babies anymore.S. Mother’s milk isn’t just for babies anymore. In the U. “Being able to give the next best alternative made me feel better.Probiotics CrazeHMO is just one part of DuPont’s larger foray into digestive health, a loosely regulated market growing 20 percent a year. The company sees an estimated 5 billion annual opportunity developing gut-health products, though some experts question whether the supplements benefit everyone.Even in nature, breast milk can vary depending on the different kinds of sugars produced by each mom., babies fed generic formulas, which are as much as 50 percent cheaper, have outcomes “every bit as good’’ as those fed pricier formulas, Abrams said. Nestle last year rolled out HMO formula in Gerber and other brands across 40 countries. Meanwhile, it’s partnering with Lonza Group AGto make enough product to meet current demand. An animal study at Abbott’s labs showed that HMO stimulated the vagus nerve, “a superhighway communicating from gut to brain,” she said. and BASF SE are investing millions to ramp up production of an indigestible sugar found naturally in breast milk.

HMO escapes digestion, allowing it to reach the colon where it feeds beneficial bacteria. and Europe late last year.A breast Milk Ingredient is the hot new health supplement for adults as study says it can boost immunity and sharpen brain.Abbott Laboratories in 2016 was the first to add HMO to infant formula in its Similac brand.S. The company touts its Holigos IBS product as managing symptoms of irritable bowel syndrome, including abdominal pain, constipation diarrhea and bloating. “BASF will have a pipeline of science-driven products with substantial health benefits of HMOs in the near future. “It’s not,” said Abrams, a Dell Medical School professor at the University of Texas at Austin. DuPont and BASF are focusing on making the most common version of HMO, which consists of the 2’FL sugar.Danish biotechnology company Glycom S/A is targeting the adult digestive health market with HMO supplements it began selling in the U. Abrams, chair of the American Academy of Pediatrics committee on nutrition.“Never assume that the addition of a component of human milk actually makes the formula like human milk,’’ said Steven A. HMOs nourish bacteria that “train’’ immune system cells, 80 percent of which reside in the gut, said Jose Saavedra, Nestle chief medical officer.“It’s just been a fascinating treasure trove of benefits that we’ve uncovered,’’ Buck said.”Commercial production is typically accomplished through a fermentation process using giant vats filled with microbes genetically engineered to produce specific HMO varieties, such as 2’FL.

That’s where the benefits can be seen most clearly, according to Nestle’s Saavedra: Babies getting 2’FL from their mothers have slightly lower rates of acute infection than babies whose moms are deficient in that HMO.DuPont is researching how to produce more of the 130 or so HMO varieties found in breast milk as the company identifies those with the most potential health benefits, Mukherjea said.”Smaller rivals making the ingredient include closely held Jennewein Biotechnologie GmbH and FrieslandCampina of Germany.HMOs could lead to treatments for adult ailments such as irritable bowel syndrome, allergies and even the aging brain, Buck said.“This is just the beginning for HMO,’’ she said.HMOs are known as prebiotics, nourishing desirable microorganisms that occur naturally or from probiotics.Next Best“With a mom who can’t give breast milk, you kind of feel deficient,’’ Haydock said.In babies, HMOs strengthen the developing immune system, helping fight infection and inflammation while aiding brain development, according to early research.

“This has the potential to help both brain development early in life and, later in life, brain decline. DuPont estimates the annual market could reach 1 billion. Global chemical giants DowDuPont Inc..“Our aim is to expand on our scientific know-how on specific health functions of HMOs to adults as well,” said Stefan Ruedenauer, BASF director of human nutrition research and development. Infant formula makers like Nestle SA can’t get enough of the synthetic ingredient.S. New studies show those benefits may extend to people of all ages, fitting neatly into consumers’ growing fascination with probiotics — the “good” bacteria that can help keep a human body healthy.The health claims propelled about 600 million in sales of HMO formula last year for each of Abbott and Nestle SA. Global chemical giants DowDuPont Inc. baby nutrition market in 2016.DuPont plans to spend 40 million building out its HMO production capacity this year, its second biggest capital investment after expanding a factory that makes Tyvek. DuPont is already a leader in probiotics, offering the widest variety of bacteria strains and operating the world’s largest probiotics fermentation plant, in Rochester, New York. It’s now expanded to 15 countries. More HMO varieties are already in the commercial pipeline. Concerned about the development of his digestive system, she fed him Similac with HMO